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Titre : Optimal control analysis of COVID-19 and tuberculosis co-dynamics analysis.

Auteurs : M. S. Goudiaby, L. D. Gning, M. L. Diagne, H. Rwezaura, J. M. Tchuenche

Du labo : Mouhamadou Samsidy GOUDIABY,

Résumé : uberculosis and COVID-19 are among the diseases with major global public health concern and great socio- economic impact. Co-infection of these two diseases is inevitable due to their geographical overlap, a potential double blow as their clinical similarities could hamper strategies to mitigate their spread and transmission dynamics. To theoretically investigate the impact of control measures on their long-term dynamics, we formulate and analyze a mathematical model for the co-infection of COVID-19 and tuberculosis. Basic properties of the tuberculosis only and COVID-19 only sub-models are investigated as well as bifurcation analysis (possibility of the co-existence of the disease-free and endemic equilibria). The disease-free and endemic equilibria are globally asymptotically stable. The model is extended into an optimal control system by incorporating five control measures. These are: tuberculosis awareness campaign, prevention against COVID- 19 (e.g., face mask, physical distancing), control against co-infection, tuberculosis and COVID-19 treatment. Five strategies which are combinations of the control measures are investigated. Strategy B which focuses on COVID-19 prevention, treatment and control of co-infection yields a better outcome in terms of the number of COVID-19 cases prevented at a lower percentage of the total cost of this strategy.

Journal : Informatics in medicine unlocked

Volume : 28

Pages ou Numéro article : 100849

Année : 2022

DOI : https://doi.org/10.1016/j.imu.2022.100849

Date de publication : 15 January 2022

Lien de la publication : Voir ici